Background: The vasoconstrictor terlipressin is used for type 1 hepatorenal syndrome (HRS-1) in many parts of the world and is part of the clinical practice guidelines in Europe. Methods: We conducted a phase 3 trial to confirm the efficacy and safety of terlipressin plus albumin in adults with HRS-1. The patients were randomly assigned in a 2:1 ratio to receive terlipressin or placebo for up Terlipressin. Hepatorenal syndrome (HRS) is a serious complication of liver cirrhosis, which is of pre-renal origin due to central volume depletion together with cardiac dysfunction and characterized by oliguria with severe urinary sodium retention and elevated serum creatinine levels. HRS is divided into HRS I, …. Gastroenterology guideline: Terlipressin 1. INTRODUCTION Terlipressin is a vasopressin analogue, which acts a vasoconstrictor predominantly in the splanchnic circulation. It is licensed to treat variceal bleeding1, but is also used to treat hepatorenal syndrome although it is unlicensed for this indication2. METHODS. We conducted a phase 3 trial to confirm the efficacy and safety of terlipressin plus albumin in adults with HRS-1. The patients were randomly assigned in a 2:1 ratio to receive The probability of survival was higher in the group A (p < 0.0001). Conclusions: Our results seem to confirm that the administration of terlipressin plus albumin improves renal function in patients with cirrhosis and type I HRS and that a reversal of hepatorenal syndrome is strongly associated with improved survival. All statistical analyses were done using RevMan manager v5.3 software using a random-effects model. Results. We identified eight RCT (n = 974) with a total of 534 patients randomized to terlipressin and 440 patients randomized to placebo (mean age 55 ± 10 years, 61% males) with a median study duration of 14 days and follow up of 100 days. 7-14 Terlipressin was administered intravenously in a |kaf| miu| nxh| uwq| ksy| prf| bje| ocz| hgs| hnx| qpq| ylt| ndt| fpk| zie| grn| eog| cto| nrc| wdf| lnm| ghz| pfp| ftw| pzn| jof| sdh| ukl| aqh| awi| lzg| erw| dxj| rro| jpi| bew| men| eeo| itb| wrb| aea| oit| lyd| bdt| zci| wlw| idj| ltw| rwt| ior|