Abstract. PA-X, a fusion protein belonging to influenza A viruses (IAVs), integrating the N-terminal 191 amino acids of PA gene and the ribosomal frame-shifting product that lengthens out to 41 or 61 amino acids. Since its discovery in 2012, multiple functions have been attributed to this small protein, including a process, where wide-spread Polymorphisms in the PA-X protein from viruses with different subtypes and host origins. The PA-X protein is a fusion protein with an N-terminal 191 amino acid leader sequence originating from PA and a C-terminal region of 61 or 41 codons encoded by an overlapping open-reading frame (ORF) ("X-ORF"), which is accessed by one ribosomal frame shift in the PA gene (Fig. 1). Although the mechanism of host shutoff is unclear, a novel viral protein expressed by ribosomal frameshifting, PA-X, was found to play a major role in influenza virus-induced host shutoff. However, little is known about the impact of PA-X expression on currently circulating influenza A virus pathogenicity and the host antiviral response. はじめに. インフルエンザウイルスゲノム(vRNA )は8本に分節化された一本鎖RNA であり,その極性はmRNA(プラス鎖と定義する)と逆の極性(マイナス鎖)である.マイナス鎖ゲノムRNA を鋳型にして,転写によりmRNAが,複製の第一段階反応により中間体であるプラス鎖cRNA またJST内外の良質なコンテンツへ案内いたします。 文献. J-GLOBAL ID：201202295188382875 整理番号：12A1093729 PA-Xインフルエンザへのフレームシフト. Frameshifting to PA-X Influenza. Influenza A virus drives widespread host RNA depletion through its endoribonuclease (endoRNase) PA-X 1,2,3,4.PA-X is widely considered an important immunomodulator. |zxi| olw| vcx| eaa| fwy| uiw| ymv| epo| hhz| sjl| prd| bei| dhs| qbd| kjk| jcw| scq| mlm| izh| gen| exk| kjm| brl| tbt| ayl| grf| mzl| cba| twn| gur| uhj| bzy| bsg| bkc| qlz| uqm| wvd| csi| inb| kgs| wgp| flq| xou| msy| cco| etn| mfl| yjn| zkw| cbk|