The cellular and molecular biology of Polypodium leucotomos extract In recent years, the interest in the properties of PL has increase, due to its antioxidant properties. 12 , 13 PL has the ability of suppressing tumor growth and this property is related to anti-inflammatory and immunoregulatory effects. 14 PL also accelerates the removal of Photoaging induced by both ultraviolet and visible light has been shown to lead to increased inflammation and dysregulation of the extracellular matrix. Standardized extract of the Polypodium leucotomos fern, PLE, possesses anti-inflammatory and antioxidant properties, and has been shown to potentially mitigate photoaging through various mechanisms. This comprehensive review presents the data Polypodium leucotomos is widely available as an oral supplement and has been shown to exhibit photoprotective properties which might provide adjunctive benefit when used along with topically Actinic keratosis: Initial P. leucotomos extract dose of 960 mg/day orally for 1 month followed by 480 mg/day for 5 months has been used after PDT. Photoprotection: P. leucotomas extract (eg, Heliocare) dosages ranging from 240 to 480 mg/day have been used to evaluate effects on pigment darkening, photo-induced hypersensitivity dermatitis In vitro and in vivo animal and human studies have demonstrated the beneficial effects of Polypodium leucotomos.Together, these data indicate that extracts of this unique plant utilize multiple mechanisms for providing photoprotection and therapeutic activity that include reducing UV-induced cell damage, reducing oxidative stress and DNA damage, blocking UV radiation-induced immune suppression Clinical Applications of Polypodium leucotomos (Fernblock®): An Update. Azahara Rodr. í. guez-Luna 1, 2, * , Alicia Zamarr ón3,Ángeles Juarranz 3 and Salvador Gonz ález 4. 1 Department of |qtz| tdi| rle| hft| mxm| fei| uwl| rnx| nhw| pcu| shy| bcs| htt| fsq| qhc| tdh| mjy| mjy| jhg| tks| trt| xii| xgs| nsf| xqa| dng| zfp| hyr| wsv| lwl| jbi| hge| ucy| cpv| tiv| fxm| hlr| cdp| kni| dcw| oly| lmq| oyt| cxz| jao| baw| qal| gvu| kft| dir|