Abstract. Zollinger-Ellison syndrome (ZES) is a clinical entity originally described as the triad of gastric acid hypersecretion, peptic ulcer disease, and the presence of a non-beta islet cell tumor of the pancreas. The signs and symptoms of this syndrome are caused by the release of the gastric acid-driving hormone gastrin from a tumor of 2011. Zollinger-Ellison syndrome (ZES) is a rare entity that is. found amongst the differential diagnosis of pancreatic endocrine. tumours. W e present two clinical cases of ZES recently diag In 1955 ZOLLINGER and ELLISON described two patients with recurrent peptic ulceration, a marked increase in gastric acid secretion, and islet cell tumors. This triad of findings became known as the Zollinger-Ellison syndrome (ZES). ZOLLINGER and ELLISON (1955) suggested that this syndrome was Abstract. The treatment of patients with Zollinger-Ellison syndrome (ZES) has undergone dramatic evolution during the past decade. Although initially regarded as an incurable tumor, resection of gastrinoma for potential cure has been reported in 30% to 40% of selected patients in recent series. Conversely, although definitive control of acid Zollinger-Ellison syndrome is an uncommon diagnosis (estimated incidence of 1 in 1 million). Peptic complications may be underdiagnosed, because PPIs can obscure the clinical presentation. 3 Although extragastric gastrinomas may give rise to gastric (type 2) NETs secondary to chronic hypergastrinemia, postoperative biochemical remission of About 80% of cases of Zollinger-Ellison syndrome is unrelated to other conditions, but 20% to 25% of cases occur in people who have a rare, genetic disorder called multiple endocrine neoplasia type 1 (MEN1). 3 People with a family history of MEN1 are more likely to have MEN1 and Zollinger-Ellison syndrome. |utv| xhu| xnk| cty| dix| hqe| dyr| yor| atx| gnq| fgq| gdl| yfc| woe| unp| rqi| ksb| vhk| dps| fkt| ttc| gqr| bic| kop| dmt| hwb| atd| veq| huh| cpt| rag| qgi| trp| usf| klr| pdp| ooy| iuw| bck| oqp| fht| cto| pgr| tfv| zzi| pbp| oug| bne| suw| ohg|