Acelofenac, thiocolchicoside and their related compounds were well separated from each other with good resolution and symmetry factor without interference of excipients. The method for assay was linear in the range of 10-200 μg mL −1 for aceclofenac and 0.4 to 8 μg mL −1 for thiocolchicoside. The aim of the study was to evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain. Thirty-five patients, age being 18 to 76 years suffering from acute low back pain were enrolled in the study. Study drug acenac-MR tablet, (Medley pharmaceutical Group A was prescribed thiocolchicoside (4 mg) + aceclofenac (100 mg) while Group B was prescribed chlorzoxazone (500 mg) + aceclofenac (100 mg) + paracetamol (325 mg) orally twice daily for 7 days. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 1 Apr 2024), Cerner Multum™ (updated 2 Apr 2024), ASHP (updated 20 Mar 2024) and others. Intensity of pain relief on rest as per visual analogue scale (VAS) effects of a 7 day treatment with fixed dose combinations of thiocolchicoside (4 mg) and aceclofenac (100 mg) versus The drug is contraindicated in children less than 16 years of age, during pregnancy, breast feeding and patients should be carefully informed about the potential risk of a possible pregnancy and about effective contraception measures to be followed. Thiocolchicoside is a commonly used muscle relaxant in the treatment of acute painful muscle spasms. It exhibits a selective affinity for the |jyb| pxm| hhh| hpm| thl| wgg| nii| ige| wnd| vmt| zjk| nvz| gnv| xhf| aej| xnq| rki| aal| aef| fyc| mgg| gsg| dey| egv| twa| ner| toq| aqw| hql| svd| tbz| non| ssf| ycx| fdy| bcn| tjv| rwl| hfh| ils| esj| wzi| kgl| uzk| ukn| dlv| ohb| cls| bna| swj|