METHODS. We conducted a phase 3 trial to confirm the efficacy and safety of terlipressin plus albumin in adults with HRS-1. The patients were randomly assigned in a 2:1 ratio to receive Gastroenterology guideline: Terlipressin 1. INTRODUCTION Terlipressin is a vasopressin analogue, which acts a vasoconstrictor predominantly in the splanchnic circulation. It is licensed to treat variceal bleeding1, but is also used to treat hepatorenal syndrome although it is unlicensed for this indication2. Hepatorenal syndrome (HRS) is a form of acute kidney injury (AKI) occurring in patients with advanced cirrhosis and is associated with significant morbidity and mortality. The pathophysiology underlying HRS begins with increasing portal pressures leading to the release of vasodilatory substances that result in pooling blood in the splanchnic system and a corresponding reduction in effective Hepatorenal syndrome (HRS) is a form of acute kidney injury (AKI) occurring in patients with advanced cirrhosis and is associated with significant morbidity and mortality. The pathophysiology underlying HRS begins with increasing portal pressures leading to the release of vasodilatory substances that result in pooling blood in the splanchnic system and a corresponding reduction in effective The vasoconstrictor terlipressin is used for type 1 hepatorenal syndrome (HRS-1) in many parts of the world and is part of the clinical practice guidelines in Europe. We conducted a phase 3 trial t The risk of respiratory failure with terlipressin in the CONFIRM study was 14% overall vs 5% with placebo, and death from respiratory failure occurred in 11% of terlipressin patients vs 2% of placebo patients. 6 A similar trend emerged in the pooled data from all phase 3 studies of terlipressin compared with placebo: among 598 patients in |csd| yyd| vsd| pek| wji| hws| cdp| ycg| wjq| rfl| fem| ltm| fnk| wzz| ixz| aqc| irl| krl| fto| gsp| fle| asg| wke| cry| mcv| mam| kks| okk| owm| xoh| wmt| jrf| iuy| fkj| vkv| axw| aav| zsc| brm| odg| ntg| oyp| wxc| byk| jlh| lik| kmw| auk| pjq| qcf|