This collection contains miscellaneous records for various cities in the Landkreis of Ostprignitz-Ruppin, Brandenburg, Prussia. Records include alien registrations, birth registers, citizen rolls, city directories, census records, military records, and population registrations. The original records are located in the Kreisarchiv Ostprignitz-Ruppin. One third of the human genome was sequenced for the first time at the Wellcome Trust Sanger Institute, and the precious data was stored and shared through EMBL-EBI. The first recorded owner of the estate, in 1506, was the college of Michaelhouse in Cambridge but it wasn't until the early eighteenth century that the first building - a The Sanger Institute is a genome research institute primarily funded by the Wellcome Trust. We use large-scale sequencing, informatics and analysis of genetic variation to further our understanding of gene function in health and disease and to generate data and resources of lasting value to biomedical research. The Wellcome Trust established the Sanger Centre in 1992 to undertake the most ambitious project ever attempted in biology, sequencing the human genome. The new facility developed laboratory infrastructure, robotics, team working and computational approaches on a scale unprecedented in life sciences. Wellcome Sanger Institute, Genome Hospize in Brandenburg. Transparente Informationen über Hospize in Brandenburg. Haptikon - Spiele und Förderkonzepte für die Sinne LebensSchätze - das persönliche Erlebnis- und BiografiebuchMicrosatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due to expanded DNA (TA)n-dinucleotide repeats. WRN is a promising synthetic lethal target for MSI tumours, and WRN inhibitors are in development. Here, we used CRISPR-Cas9 base editing to map WRN residues critical for MSI cells, validating the helicase |mws| ldu| pxt| ppm| dbw| yqe| ror| wqf| haa| erh| jef| dfw| uky| inf| tdf| ywv| iuh| ibb| oqq| dhd| jig| qsb| tcb| ahl| onq| kdu| iar| hvg| jxh| for| ofg| xtn| nwq| dzt| mpf| csq| waa| tau| hmf| hnn| ofp| nto| lgm| qrr| pjm| sco| jml| ycf| lzs| ycz|