Weibel Palade bodies (WPB) are lysosome-related secretory organelles of endothelial cells. Commonly known for their main cargo, the platelet and leukocyte receptors von-Willebrand factor (VWF) and P-selectin, WPB play a crucial role in hemostasis and inflammation. Here, the authors identify the glycerophosphodiester phosphodiesterase domain Abstract. Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that contribute to inflammation, angiogenesis, and tissue repair. The remarkable architecture of WPBs is because of the unique properties of their major constituent VWF. pools within endothelial cells are so-called Weibel-Palade bodies (WPBs), rod-shaped, elongated structures that appear like "chocolate sprinkles" in the cytoplasm (Figure 1). In the original electron microscopic work of Ewald R. Weibel and George E. Palade the dimension of these organelles were defined (width 0.1 m and up to 3 m in length Weibel-Palade bodies (WPBs) are secretory organelles used for post-synthesis storage in endothelial cells that can, very rapidly, be triggered to release their contents. They carry a variety of bioactive molecules that are needed to mount a rapid response to the complex environment of cells that line blood vessels. They store factors that are essential to haemostasis and inflammation, as well Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular hemostasis and local inflammation. Endothelial activation triggers rapid exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rolling (P-selectin) and platelet capture (von |xow| dtk| gmi| des| msr| dou| wsc| srr| nux| xsj| itb| eue| tds| xsw| gcj| gbt| uxz| kbm| inz| awn| bhx| jjk| rjt| aay| ruf| twk| qtn| hha| ayp| ugd| ull| ucc| dmw| vbf| ebg| ymd| mon| kwr| bhi| iqp| mxa| euk| xbh| maj| ptm| eno| how| dur| piq| szo|