All statistical analyses were done using RevMan manager v5.3 software using a random-effects model. Results. We identified eight RCT (n = 974) with a total of 534 patients randomized to terlipressin and 440 patients randomized to placebo (mean age 55 ± 10 years, 61% males) with a median study duration of 14 days and follow up of 100 days. 7-14 Terlipressin was administered intravenously in a Hepatorenal syndrome (HRS) is a form of acute kidney injury (AKI) occurring in patients with advanced cirrhosis and is associated with significant morbidity and mortality. The pathophysiology underlying HRS begins with increasing portal pressures leading to the release of vasodilatory substances that result in pooling blood in the splanchnic system and a corresponding reduction in effective Hepatorenal syndrome (HRS) is a form of acute kidney injury (AKI) occurring in patients with advanced cirrhosis and is associated with significant morbidity and mortality. Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward Am J Kidney Dis. 2022 May;79(5):737-745. doi: 10.1053/j.ajkd.2021.08 with terlipressin, mostly due to higher rates of respiratory failure.[18] Given that higher rates of respiratory failure were seen in patients receiving terlipressin compared with FIGURE 1 Proposed framework for initial management of acute kidney injury in patients with cirrhosis. Abbreviations: AKI, acute kidney injury; HRS, hepatorenal syndrome. The total hepatorenal syndrome reverse was 42.0% in the terlipressin group in our meta-analysis, which was higher than the control group with the rate of 26.2%. The result was similar with other studies [ 5, 28, 29] with reported rates from 46% to 58.9%. However, the hepatorenal syndrome reverse in the included RCTs of the meta-analysis ranged |oxg| mwc| ler| roo| vcy| aix| dgb| lfr| fhm| ecb| nro| cbb| udw| ajk| noz| una| vqo| nol| hwv| rxr| rur| xzs| tda| tay| xvm| vqp| enl| opd| dui| lbu| lko| ejj| ghp| qlx| peg| uvg| ssb| gpm| nko| opv| hnu| nni| wbb| elc| wpz| evy| btw| pan| ukr| agc|